Surgical Approaches to the Sphenoid Sinus and Pituitary Gland 

Presented by Sang-Hoon Chun, M.D., April 3, 1997
Comments and Supervision by Kyung Shik Suh, M.D.


HISTORICAL OVERVIEWS 

Schloffer.(1906) 
  1st extracranial approach through the nose 
  suffered from permanent nasal obstruction and crusting 
 
Von Eiselberg(1906)  included frontal sinus 
  Very large tumors even orbital exentration discribed 
  Forehead flaps to seal off CNS 
  No antibiotics, Microscope, C-arm 

Halstead (1910) 
  Gingivobuccal sulcus incision - sublabial transseptal approach 
  Resected whole septum 

Hirsch (1911) 
  Preserved normal structures and nasal function 
  Subtotal resection 
 
Cushing (1914) 
  Combined into the sublabial incision of Halstead and submucosal septal approach 
of Hirsch : lip and external nose raised as one, good exposure ,preserving nasal 
function, avoiding facial scar 
  203 transseptal hypophysectomies  7.38% mortality rate by 1922 

Transcranial approach (1930) Cushing and most American surgerns 
  removal of suprasella lesions 

Extracranial approaches to pituitary ablation in 1953 

Dott and Bailey 
  learned the transsephenoidal approach from Cushing and later introduced Guiot 

Guiot and Bouche (1960) 
  490 cases 1.9% mortality rate 

Hardy 
  transseptal transsphenoidal technic 

Kern and colleagues 
  transseptal transsphenoidal approach by way of maxilla- premaxilla approach 

Jankowski (1992) 
  endonasal endoscopic approach 

ANATOMY OF SPHENOID SINUS 

most posteriorly located of the paranasal sinuses. 
pneumatization : develop rapidly between 5 and 7 years of age 
                complete by age 20 to 25 years 

Hamberger's classification 
 Three varieties 
   Sellar type (86%) : sella floor bulging into a well developed sinus(0.4mm) 
   Presellar type (11%) : cancellous bone of the sphenoid extends from under the 
sella trucica to the anterior sapect of the floor(0.7mm) 
   Concha type (3%): sphenoid sinus is absent and entirely filled by cancellous 
bone(>10mm) 

1. Development 
    4month : indentified 
    birth : evagination of sphenoethmoid recess 
    3 yrs : begin to grow 
    after 5yrs : rapid invasion of sphenoid bone 
    7 yrs : extended posteriorly to level of sella trucica 
    late teens : aerated to dorsum sellae 

2 Anatomy 
    open into sphenoethmoidal recess 
    capacity : 0.5 - 30 ml 
    average : 7.5 ml 
    20 mm in height, 23 mm in length , 17 mm in width 
    two sphenoid sinus rarely symmetrical 
    Septum of sphenoid snius 
      deviated from the midline.(midline cases 27%) 
      oblique or transverse,vertical case(25%) 
      accessory septa  arising from synchondroses of the sphenoid 
    sinus usually asymmetircal, one much larger and overlapping the other 
    the two sinus rarely communicated 

3.Parasellar anatomy 
  lateral to the shenoid sinus 
   : cavenous sinus 
     internal carotid artery ( posterioinferior surface of the latral sphenoid sinus) 
     several cranial nerve(occulomotor, trochlear, abducens, ophthalmic, maxillary 
branch of  trigerminal nerve) 
  optic nerve and chiasm 
   : located in the anterolateral aspect of the sphenoid roof 
    4% optic canal bone - absent 
    above : middle cranial fossa and pituitary gland, olfactory tract, frontal lobe 
    laterally : carvenous sinus and teh internal carotid artery, abducens n. 
    posteriorly : posterior cranial fossa most thick bone  basillar art. ons 
    floor : nasopharynx, pterygoid fossa. 

    Pterygoid canal : 16.2mm long 
 
4.Onodi cells - Lang 
  Def. : posterosuperior ethmmoidal cells lying within the sphenoid bone 
  Sphenoid sinus solely develops in lower half of body of the sphenoid bone 
  upper body unites with ethmoid labyrinth 9-12% 
  surround the optic canal with bone (0.5 - 1.0mm) 
  reached the anterior wall of the sella trucica 

5.Recesses of the sphenodal sinus 
  Septal recess - sphenovomerine bulla 
  Ethmoidal recess 
  Superior and inferior lateral recess 
  Palatine recess 
  Inferolateral recess 
  Pterygoid recess 
  Posterioradn posterosuperior recess 

6.Drainage 
   poor drainage favor its function 
   15 % all sinusitis 
   35 % of all intracranial complication from nose 
   drainage is through the cilliary action since the ostium is located 
   1.5cm above the floor of the sinus 

   Drainage interference 
   a. narrow sphenopalatine recess 
   b. pathologic blockage : thickening of mucosa, hyperplasis, polyp 

   blood supply and innervation - similar to post. ethmoid cell 

Preoperative Evaluation 

 Active sinus infection is the primary contraindication to a transnasal intracranial 
procedure. 

APPROACH TO THE SPEHNOID SINUS 

  Absolute Indication for transnasal 
   - tumor into sphenoid sinus 
   - intrasellar microadenoma 
   - tumors with CSF leak 
 
  Absolute Contraindication 
   - sphenoid sinusitis 
   - intracranial extension 

 1.Transseptal approach 
    sublabial transseptal approach 
    intranasal transeptal approach 
    external rhinoplasty transseptal approach 
    collumellar flap modification 

 2.Transantral approach 

 3.Transethmoidal approach 
    external approach 
    intranasal approach 

 4.Transpalatal approach 
 5.Endoscopic endonasal pituitary surgery 

SURGIICAL APPROACH 

1.Transseptal sphenoidectomy 

Sublabial transseptal approach 
   after general anesthesia 
   1% lidocaine with 1:100,000 epinephrine 
     - injected into the upper buccal sulcus, septum, floor of the nose. 
   incision  upper labial sulcus 
     - approximately 5mm superior to the junction between gingiva &  mucosa 
   premaxillary periostium elevation. 
   bone and nasal spine is resected as needed for exposure. 
   perichondrium is incised over the caudal end of the right side of the nasal septum. 
   mucoperiostium is elevated from the inferior lip of th pyriform aperture 
                                       floor of the nose bilaterally 
   dissection continue on the right side along the lateral wall of the maxillary crest 
                                superiorly along the right cartilage and bony septum 
   left nasal floor mucosa elevated the same method but left septal mucosa is left intact 
   catilaginous septum is dislocated form the perpendicular plate & maxillary crest 
    displaced into the naris 
   perpendicular plate of the septum is removed until only vomer remaims 
   neurosurgical pituitary speculum insertion 
   sphenoid sinus is entered int the midline with use of the operationg microscope. 
     - sphenoid ostia used initially as the superior and lateral landmarks for safe removal of the anterior sinus wall 
   resection of septa 


External rhinoplasty - Transseptal approach 
   standard rhinoplasty incision 
   columellar flap is raised onto the nasal dome. 
     (elevation - only midway over the lower lateral cartilage ) 
   medial crura separated by incising the intercrural ligaments 
   Exposing the caudal edge of the quadrilateral crtilage 
   and then traditional transseptal approach is continued. 
 
Septal translocation approach 
   supine position, head rotated to the right 
   xylocaine infiltration as for septoplasty 
   hemitransfixion incision  made ipsilatral to the side of pathologic involvement 
   elevation of the mucoperichondrium/periosteum from the septum of the contralateral side 
   vomer and  perpendicular ethmoid plate removed 
   mucosa along the floor ipsilateral to the mass is incised from the lower aspect of  the hemitransfixion incision anteriorly to the posterior choana 
   incision : midline of the nasal floor 
   contralateral mucoperichondrium/periosteum elevated from septum, maxillary crest and  nasal floor 
   transverse sublabial incision 
   maxillary crest rmoved with rongeurs and chisels 
   self retaining hypophysectomy retractor insertion 
   sphenoethmoid complex - surgical manuplation 
 

2. Transethmoidal sphenoidectomy 

External approach 
  endotracheal anesthesia 
  protection of eye : lubricant and a tarsorrhaphy stitch 
  xylocaine injection : septum, trubinates 
  incision : curvilinear, extending from below the eyebrow inferiorly along the lateral nasal wall, halfway between the inner canthus and the dorsum of the nose 
  elevation of periosteum : along the lateral aspect of the lacrimal and ethmoid bone, 
  gently retraction of orbital contents 
  mobilize the lacrimal sac from surrounding anterior and posterior lacrimal crest 
  incise the medial canthal ligament 
  blunt dissection : reveal lamina papyracea and frontoethmoid suture line 
  anterior ethmoidal artery : clipped or electrocauterization 
  posterior ethmoidal artery : preservation for landmark of optic nerve 
    cf) Anatomic landmark 
        anterior ethmoidal artery - 24mm posterior to the posterior lacrimal crest 
        posterior ethmoidal artery - 12mm posterior to the anterior vessel 
        optic nerve - 6mm posterior to the posterior ethmoidal artery 
        frontoethmoid suture line - identifying the level of the anterior cranial fossa 
 
   exposing the lacrimal bone, rontal process of maxilla, lamina papyracea, orbital process of frontal bone 
   enter the ethmoid cells through the lacrimal fossa 
   removal of ethmoid cells sequentially 
   exposed anterior wall of sphenoid sinus 
   removal of anterior wall of sphenoid sinus and septum of sphenoid sinus 

Intranasal 

3.Endoscopic endonasal approach of sphenoid sinus

Indication

1) CT evidence of sphenoid disease
: opacification, air-fluid level, mucocele or mucosal thickening > 2mm
2) Evidence of sphenoid obstruction on endoscopic exam
: edematous tissue, polyps or mucoprulent drainage
3) Recurrent vertex or retro-orbital headache in the prescence of radiologic endoscopic evidence of paranasal sinus disease

Anesthesia
  general anesthesia 
  xylocaine injection to the septum, nasal floor, turbinate 
  recognition of the both the arch of the choana and the end of middle turbinate 

Superior turbinate
: key landmark for identification of sphenoid ostium in both approach

Transnasal approach

Lateral displacement of middle turbinate with a Freer elevator
Identification of the superior turbinate alonside the nasal septum
: more inferiorly located superior turbinate than initially expected
Cutting the superior attachment of the superior turbinate with a turbinate scissors
Grasping the trasected turbinate with a Blakesley forceps
Displacement of the forceps downward with a gentle twisting motion
Identification of sphenoid ostium with spoon curette
: located medial to the superior turbinate remnant at the point when its course along the face of the sphenoid change from a vertical to a transverse direction
Enlargement of the ostium in an inferior and medial direction with spoon curette, Hayek forceps or bone rongeur
: keep the curette medial to the superior turbinate attachment when the sphenoid ostium is being enlarged due to reduce the injury of skull base, optic nerve or carotid artery
: pass medial to the middle turbinate into the sphenoethmoid recess
: direct approach to sphenoid ostium through the sphnoehtmoid recess
Identifying the location of the optic nerve and carotid canal along the lateral sphenoid wall
Removal of remaining anterior wall of the sphenoid opening
: optimal size of ostium widening : 5-10 mm

Transethmoid approach
: pass lateral to the middle turbinate
: most suitable for coexistent sphenoid and ethmoid disease through the ethmoid sinus

Endoscopic ethmoidectomy
Identification of the sphenoethmoid angle
: where the roof of the posterior ethmoid sinus meets the face of the sphenoid sinus
Passing a Freer elevator in a posterior direction along the lateral surface of the middle turbinate
Cutting the superior attachment of the superior turbinate with a turbinate scissors
Grasping the trasected turbinate with a Blakesley forceps
Displacement of the forceps downward with a gentle twisting motion
Identification of sphenoid ostium with spoon curette
: located between the superior turbinate remnant and the sphenoid sinus in the sphenoethmoid recess
Enlargement of the ostium in an inferior and medial direction
Identifying the location of the optic nerve and carotid canal along the lateral sphenoid wall
Further enlargement of the sphenoid opening
: optimal size of ostium widening - 10 mm
natural ostium
  sphenoid sinus lies at medial inferior portion of the posterior ethmoidal cell 
  anterior wall of sphenoid sinus - 7cm posterior the anterior nasal spine open inferior and lateral 
  remember the anatomic variations in the relationship between the optic canal and Onodi  cell  -  distance to the posterior wall of sphenoid sinus (9cm) 

 
COMPLICATIONS OF SPHENOID SINUS SURGERY 

Nasal complications 
  Cosmetic (saddle and tip deferomities) 
  Septal perforation 
  Infection 
  Epistaxis 

Neurologic complications 
  Injury to optic nerve and cranial nerves III,IV,V1,V2 
  Trauma to optic chiasm 
  Late prolapse of chiasm into sella 
  Trauma to hypothalamus 
  Cerebrospinal fluid leak 

Vascular complications 
  Hemorrhage from internal carotid artery 
  Hemorrhage from cavernous sinus plexus 

EMERGENCIES OF SPHENOID SINUS 

Preoperative state 
 Acute sinustis with meningitis or other neurologic signs 
   - Surgical drainage 
 Developing visual loss in sellar / parasellar tumor 
   - surgical decompression, radiation therapy 

Intraoperative state 
 Retrobulbar hemorrhage with proptosis and visual compromise 
   - lateral canthotomy, opthalmology consultation 
 Persistent hemorrhage from sphenoid or carvenous sinus region 
   - interventional arteriography 
 


References :

1. Bailey et al, Approaches to the sphenoid. Head and Neck Surgery-Otolaryngology, 1st Ed. Vol 1, p402-12, J.B. Lippincott, Philadelphia, 1993.

2. Bailey et al, Intranasal sphenoidectomy, Atlas of Head and Neck Surgery-Otolaryngology, 1st Ed p874-7, J.B. Lippincott, Philadelphia, 1993.

3. Johannes Lang, Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses, Thieme Medical Publishers, New York, 1989.

4.Ralph Metson, Richard E,Gliklich , Endoscopic treatment of sphenoid sinusitis, Otolaryngol Head and Neck Surg 1996 ; 114 : 736-44.

5.Steven D, Endoscopic sinus surgery : Posterior approach, Operative technices in Otolaoryn- gology - Head and Neck Surg 1990 ; 1: 104-7.